Physician Profile

Santhanam Lakshminarayanan, M.D.

Associate Professor of Medicine, Department of Medicine, Division of Rheumatology, UConn Health
Director, Rheumatology Fellowship Program, UConn School of Medicine
UConn Musculoskeletal Institute

Dr. Santhanam Lakshminarayanan is an Associate Professor of Medicine in the Division of Rheumatology at UConn Health. Dr. Lakshminarayan is a graduate of The Armed Forces Medicial College in Pune India and earned his M.B.B.S. for the University of Poona, India. He completed his residency and rheumatology fellowship training at the UConn School of Medicine. He joined the Rheumatology faculty in 2002. He is the director of the Rheumatology Fellowship Program. He is responsible for training two to four fellows per year and for overseeing four training sites, the UConn Health Center, St. Francis Hospital & Medical Center, VA Medical Center in Newington, and Connecticut Children's Medical Center. He is also director of the Rheumatology Fellow Journal Club and involved in weekly didactic review at rheumatology patient management rounds and rheumatology teaching rounds. He is on the medical advisory board for the Lupus Foundation of America, Connecticut Chapter, American College of Rheumatology (ACR) subcommittee for medical student and resident education, and ACR New England OSCE program developemnt for rheumatology fellows. Dr. Lakshminarayanan's areas of expertise are in Lyme disease, gout and systemic rheumatic disease. He has published articles on systemic lupus erythematous. Dr. Lakshminarayanan conducts clinical trials on scleroderma, Raynaud's phenomenon, systemic lupus erythematosus and inflammatory arthritis.

Office Locations:

UConn Health
Outpatient Pavilion, 3rd Floor West
263 Farmington Avenue
Farmington, CT 06030

800 Connecticut Boulevard, 1st Floor
East Hartford, CT 06108

Board Certifications:
  • Internal Medicine
  • Rheumatology
Education and Training:
Medical SchoolArmed Forces Medical College Medicine
Medical SchoolUniversity of PuneMedicine
InternshipEdgware General HospitalInternal Medicine
InternshipGovernment General Hospital
ResidencyUniversity of Madurai, Rajaji HospitalInternal Medicine
OtherRoyal Preston HospitalSenior House Officer in Medicine, Nephrology, Neurology and Intensive Care Medicine
ResidencyUniversity of Connecticut School of MedicineInternal Medicine
FellowshipUniversity of Connecticut School of MedicineRheumatology
OtherRoyal Liverpool University HospitalSenior Registrar in Rheumatology
Honors and Awards:
Name of Award/HonorAwarding Organization
Major General N.D.P.Karani Trophy for academic achievement In Medical School.
Second best All Round Student Graduating class
Hospital Affiliation:
  • UConn John Dempsey Hospital
Research Interests:

Scleroderma, systemic lupus erythematous, and use of P32 radioactive synovectomy in refractory inflammatory monoarthritis

Languages Other than English:
  • Hindi
  • Tamil
Selected Publications:

Peer Reviewed Publications

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial. Khanna, Dinesh; Denton, Christopher P; Jahreis, Angelika; van Laar, Jacob M; Frech, Tracy M; Anderson, Marina E; Baron, Murray; Chung, Lorinda; Fierlbeck, Gerhard; Lakshminarayanan, Santhanam; Allanore, Yannick; Pope, Janet E; Riemekasten, Gabriela; Steen, Virginia; Müller-Ladner, Ulf; Lafyatis, Robert; Stifano, Giuseppina; Spotswood, Helen; Chen-Harris, Haiyin; Dziadek, Sebastian; Morimoto, Alyssa; Sornasse, Thierry; Siegel, Jeffrey; Furst, Daniel E. (2016). Lancet (London, England),

Finger Flexion Deformity and Carpal Tunnel Syndrome Caused by Gouty Tophus. Kumar, Varinder; Rodner, Craig; Lakshminarayanan, Santhanam. (2015). The Journal of rheumatology, 8, (42), 1530-1.

Scleroderma renal crisis as an initial presentation of systemic sclerosis: a case report and review of the literature. Logee, Kristin M; Lakshminarayanan, Santhanam. (2015). Clinical and experimental rheumatology, 4 Suppl 91, (33), S171-4.

Validation of a novel radiographic scoring system for calcinosis affecting the hands of patients with systemic sclerosis. Chung, Lorinda; Valenzuela, Antonia; Fiorentino, David; Stevens, Kathryn; Li, Shufeng; Harris, Jonathan; Hutchinson, Charles; Assassi, Shervin; Beretta, Lorenzo; Lakshminarayanan, Santhanam; Rodriguez-Reyna, Tatiana S; Denton, Christopher P; Taillefer, Rebecca G; Herrick, Ariane L; Baron, Murray; Scleroderma Clinical Trials Consortium Calcinosis Working Group. (2015). Arthritis care & research, 3, (67), 425-30.

Exercise during cardiac catheterization distinguishes between pulmonary and left ventricular causes of dyspnea in systemic sclerosis patients. Hager, W David; Collins, Irina; Tate, Janet P; Azrin, Michael; Foley, Raymond; Lakshminarayanan, Santha; Rothfield, Naomi F. (2013). The clinical respiratory journal, 3, (7), 227-36.