Physician Profile

Bruce T. Liang, M.D., F.A.C.C.

Director, Pat and Jim Calhoun Cardiology Center
Chief, Division of Cardiology
Ray Neag Distinguished Professor of Vascular Biology
Overview:

Dr. Liang is a fellow of the American College of Cardiology, the American Heart Association and the Council on Clinical Cardiology and Basic Cardiovascular Sciences. He is also a member of the American Society for Clinical Investigation.

Specialties:
Office Locations:

Pat and Jim Calhoun Cardiology Center
UConn Health
263 Farmington Avenue
Farmington, CT 06030
860-679-3343
Directions

Board Certifications:
  • Internal Medicine
  • Cardiovascular Disease
Education and Training:
TrainingInstitutionMajor/Specialty
Undergraduate SchoolHarvard CollegeBiochemistry and Molecular Biology
Medical SchoolHarvard Medical SchoolMedicine
InternshipHospital of the University of PennsylvaniaMedicine
ResidencyHospital of the University of PennsylvaniaInternal Medicine
FellowshipBrigham and Women's HospitalMedicine (Research/Clinical)
FellowshipHarvard Medical SchoolMedicine (Research)
Hospital Affiliation:
  • John Dempsey Hospital
Honors and Awards:
Name of Award/HonorAwarding Organization
Blue Precision Designation in CardiologyAnthem Blue Cross and Blue Shield
Elected as a Member of the Connecticut Academy of Science and EngineeringConnecticut Academy of Science and Engineering
National Steering Committee of LEADERS in Clinical Weight Management
Development of a New Method to Detect Heart Failure via a Simple Blood Test
Lifetime Member of Global Who's Who
Named an America’s Top Doctor by Castle Connolly in Cardiovascular Disease Since 2006Castle Connolly Medical Ltd.
Elected and Inducted into the Association of University CardiologistsAssociation of University Cardiologists
Elected and Inducted into the American Society for Clinical InvestigationAmerican Society for Clinical Investigation
Established Investigatorship, 1993-1998 American Heart Association
First Place, Mead Johnson Excellence of Research Award National Student Research Forum
First Place, Roche Laboratories Award in Basic Sciences, National Student Research ForumRoche Laboratories
Research Interests:

Dr. Liang’s research program has focused on the fundamental signaling mechanisms that regulate cardiovascular functions. Using the concepts and tools of biochemistry and molecular biology, integrated with a cellular and pharmacological approach, the program has addressed and elucidated novel functions and signaling mechanisms for the various purinergic receptors in the heart. Two tracks of development have evolved new directions and models relevant to advances in cardiovascular research. The first direction is exemplified by the development of a novel cardiac cell model for cardioprotection and ischemic preconditioning. The development of efficient cardiac myocyte transfection enables the use of an approach to delineate mechanism and to develop new receptor ligands important in protecting the myocyte against ischemia. This model is now widely recognized and is currently used by different laboratories. Certain basic observations, for example, those related to his studies on the cardiac adenosine A3 receptor, have been repeated and investigated further by others. His research has yielded new insights on the fundamental mechanisms of cardiac myocyte protection. In a second example, a new transgenic mouse line overexpressing a novel P2X purinergic ligand-gated receptor channel shows enhanced basal cardiac contractility and relaxation. This transgenic line provides the proof of principle that this ligand-gated channel is a potential novel therapeutic target for the treatment of heart failure.

It is anticipated that the program will continue to develop new translational/clinical research projects. Some examples of such research include the ongoing studies on novel purine receptors and their ligands in protecting the ischemic myocardium and in treating heart failure. Study on identifying novel mutations of the adenosine transporter represents another example. Overall, He has had continuous NIH support for the last 16 years. His work advances novel concepts on signaling mechanisms and receptor function. He is an internationally recognized expert on adenosine receptor biology and myocyte function.

Selected Publications:


Peer Reviewed Publications

Cardiac P2X Purinergic Receptors as a New Pathway for Increasing Na+ Entry in Cardiac Myocytes. Shen, Jian-Bing; Yang, Ronghua; Pappano, Achilles J; Liang, Bruce T. (2014). American journal of physiology. Heart and circulatory physiology, ajpheart.00553.2014.

Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Yang, Tiehong; Shen, Jian-bing; Yang, Ronghua; Redden, John; Dodge-Kafka, Kimberly; Grady, James; Jacobson, Kenneth A; Liang, Bruce T. (2014). Circulation. Heart failure, 3, (7), 510-8.

CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. Pereira, Flavia E; Cronin, Chunxia; Ghosh, Mallika; Zhou, Si-Yuan; Agosto, Mariela; Subramani, Jaganathan; Wang, Ruibo; Shen, Jian-Bing; Schacke, Wolfgang; Liang, Brannen; Yang, Tie Hong; McAulliffe, Beata; Liang, Bruce T; Shapiro, Linda H. (2013). Cardiovascular research, 1, (100), 74-83.

The therapeutic effect of 2-cyclohexylthio-AMP in heart failure. Zhou, Siyuan; Yang, Tiehong; Jacobson, Kenneth A; Liang, Bruce T. (2013). Journal of cardiovascular pharmacology, 6, (61), 553-9.

5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity. Kumar, T Santhosh; Yang, Tiehong; Mishra, Shilpi; Cronin, Chunxia; Chakraborty, Saibal; Shen, Jian-Bing; Liang, Bruce T; Jacobson, Kenneth A. (2013). Journal of medicinal chemistry, 3, (56), 902-14.