Physician Profile

Joseph Lorenzo, M.D.

Professor of Medicine, Division of Endocrinology and Metabolism, UConn Health
Director of Bone Biology Research, UConn Health
UConn Musculoskeletal Institute

Dr. Lorenzo is a professor of medicine in the Division of Endocrinology and Metabolism at UConn Health. He is a nationally renowned expert in endocrinology and metabolic bone diseases. Dr. Lorenzo's clinical interests center on the management of patients with osteoporosis and other metabolic bone disorders. He was named a "Top Doctor in Endocrinology" by U.S. News and World Report for 2011.

Dr. Lorenzo’s research interests center on the regulation of bone remodeling by hormones and cytokines and the interaction of the immune and skeletal systems. He is a founding member of the organizing committee for a series of international conference on "Osteoimmunology: Interactions of the Immune and Skeletal Systems," which have occurred every two years since 2006 and an editor of a textbook on Osteoimmunology. He is also an author of the chapter "Metabolic Bone Disease" in Williams Textbook of Endocrinology (editions 10, 11 and 12). Dr. Lorenzo is a councilor of the American Society for Bone and Mineral Research, a former deputy editor of the Journal of Bone and Mineral Research and currently a member of the editorial boards of the Journal of Clinical Investigation and the journal Bone.

Office Locations:

Center for Osteoporosis
UConn Musculoskeletal Institute
UConn Health
263 Farmington Avenue
Farmington, CT 06030

Board Certifications:
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
Education and Training:
Undergraduate SchoolRensselaer Polytechnic InstitutePhysics
Medical SchoolState University of New York, Downstate Medical CenterMedicine
InternshipUniversity of Illinois Hospital & ClinicMedicine
ResidencyUniversity of Illinois Hospital & ClinicInternal Medicine
FellowshipUniversity of Connecticut School of MedicineEndocrinology/Metabolism
Hospital Affiliation:
  • John Dempsey Hospital
Honors and Awards:
Name of Award/HonorAwarding Organization
Career Development Award, 1983-1988 VA Research Associate
New Investigator Research Award, 1982-1985 NIH
Clinical Interests:

Diabetes and metabolism, endocrinology, osteoporosis, and metabolic bone disease

Research Interests:

Basic Science Research Interests

The influence of hormones and cytokines on both bone resorption, which is mediated by osteoclasts, and bone formation, which is mediated by osteoblasts.

The nature and regulation of osteoclast precursor cells in health and disease.

The influence of the immune system on bone remodeling.

Dr. Lorenzo’s laboratory is actively involved in research that is designed to identify the surface markers of cells that differentiate into osteoclasts in vitro and in vivo. The goal of these studies is to characterize the cells that form osteoclasts and determine if there are different between them in normal and pathologic conditions. It is hoped that this research will lead to the development of targeted therapies that selectively inhibit pathologic osteoclast formation without affecting normal bone turnover.

Clinical Research Interests

The role of hormones in the regulation of serum sclerostin.

The role of hormones in the regulation of osteoclast precursor cells.

Selected Publications:

Peer Reviewed Publications

Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy. Adapala, Naga Suresh; Holland, Danielle; Scanlon, Vanessa; Barbe, Mary F; Langdon, Wallace Y; Tsygankov, Alexander Y; Lorenzo, Joseph A; Sanjay, Archana. (2014). Bone, (67), 1-9.

Altered hematopoietic stem cell and osteoclast precursor frequency in cathepsin K null mice. Jacome-Galarza, Christian; Soung, Do Yu; Adapala, Naga Suresh; Pickarski, Maureen; Sanjay, Archana; Duong, Le T; Lorenzo, Joseph A; Drissi, Hicham. (2014). Journal of cellular biochemistry, 8, (115), 1449-57.

Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b. Adapala, Naga Suresh; Barbe, Mary F; Tsygankov, Alexander Y; Lorenzo, Joseph A; Sanjay, Archana. (2014). Journal of cellular biochemistry, 7, (115), 1277-89.

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. Jacome-Galarza, Christian E; Lee, Sun-Kyeong; Lorenzo, Joseph A; Aguila, Hector Leonardo. (2013). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 5, (28), 1203-13.

Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels. Jastrzebski, Sandra; Kalinowski, Judith; Stolina, Marina; Mirza, Faryal; Torreggiani, Elena; Kalajzic, Ivo; Won, Hee Yeon; Lee, Sun-Kyeong; Lorenzo, Joseph. (2013). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 3, (28), 618-26.