Physician Profile

Paul Richard Skolnik, M.D., FACP, FIDSA

Professor of Medicine
Chairman, Department of Medicine

Dr. Skolnik, a nationally prominent infectious diseases clinical specialist and academician, is professor and chairman of the Department of Medicine at the UConn School of Medicine. Dr. Skolnik previously served as professor of medicine at Boston University School of Medicine, where he has served as chief of the Section of Infectious Diseases, founding director of the Center for HIV/AIDS Care and Research at Boston Medical Center (BMC) and program director of the Infectious Diseases Fellowship Program at BMC, among other responsibilities.A graduate of Yale University and the University of Pennsylvania School of Medicine, where he also completed his internship and residency in internal medicine, Dr. Skolnik's career has focused on infectious diseases since completing his fellowship at Massachusetts General Hospital/Harvard Medical School. Before joining Boston University School of Medicine and BMC in 2001, he was on the faculty of Tufts University School of Medicine-New England Medical Center, where he served as associate program director of the General Clinical Research Center, among other responsibilities.Dr. Skolnik is a standing member of the NIH AIDS Immunology and Pathogenesis Study Section and has a substantial record of serving as a mentor for successful basic and clinical research trainees on NIH-funded T32 training grants and K08 awards. His clinical research interests include studies of HIV-related therapeutics, adherence and retention in care. He has been site leader for the Clinical Research Site of the AIDS Clinical Trials Unit at BMC.His current basic research interests include Toll-Like Receptor (TLR)-mediated innate immune responses, modeling of cytokine and chemokine networks, and the interactions of microRNAs with the innate immune system in the lungs of patients who are HIV-positive. At UConn, he will continue his research pursuits and will see patients in the Division of Infectious Diseases.

Office Locations:

Infectious Diseases
UConn Health
Dowling North Medical Building
263 Farmington Avenue
Farmington, CT 06030

Board Certifications:
  • Internal Medicine
  • Infectious Disease
  • HIV Specialist
Education and Training:
Undergraduate SchoolYale University Music
Medical SchoolUniversity of PennsylvaniaMedicine
InternshipHospital of the University of PennsylvaniaMedicine
ResidencyHospital of the University of PennsylvaniaMedicine
FellowshipMassachusetts General Hospital, Harvard Medical SchoolClinical and Research Fellow, Infectious Disease Unit
Hospital Affiliation:
  • John Dempsey Hospital
Honors and Awards:
Name of Award/HonorAwarding Organization
Best Doctors 2011, Infectious Diseases in HartfordHartford Magazine
Best Doctors, Infectious Diseases, 2007Boston Magazine
Top Doctors, Infectious Diseases, in Boston Boston Magazine
Faculty Member Recognized for Excellence in Teaching, Medicine Clerkship 2000-2001, New England Medical Center Tufts University School of Medicine
Abstract Selected as One of Two Out of More than 800 to Represent the Assembly on Microbiology, Tuberculosis, and Pulmonary Infections for the Assembly Highlights at the 97th American Thoracic Society Meetings, San FranciscoAmerican Thoracic Society
Best Doctors, 1997Boston Magazine
Best Doctors in America: Northeast Region, 1996-2009
Mary Ellis Bell Award for Outstanding Medical Research
Dr. Spencer Morris Award to the Graduating Student Who Passes the Best Examination for the Degree of Doctor of Medicine
AOA, Junior Year University of Pennsylvania School of Medicine
Phi Beta Kappa, Departmental Honors in MusicYale University
Research Interests:

Dr. Skolnik has both basic and clinical research interests related to HIV infection. Dr. Skolnik became the first director of the Center for HIV/AIDS Care and Research at Boston University Medical Center (BUMC) in July 2001. In this capacity, he oversees all aspects of clinical care, clinical research, and basic research concerning HIV/AIDS at BUMC. Dr. Skolnik is site Principal Investigator on the Harvard/Boston Medical Center Adult AIDS Clinical Trials Group (ACTG). During his time at Tufts-New England Medical Center, he initiated and directed the AIDS Research Laboratory in the Division of Infectious Diseases, the Immunovirology Laboratory of the Lifespan-Tufts-Brown Center for AIDS Research (CFAR), and was Associate Program Director of the NIH-funded General Clinical Research Center. Dr. Skolnik was one of the first to describe the bidirectional interactions between HIV and cytomegalovirus (CMV) in tissue culture and to identify infection of individual cells from retinal tissue with both HIV and CMV. His current research interests include factors affecting innate immune responses in the lung; mathematical modeling of cytokine/chemokine networks in the lung; and microRNA and microparticle control of immune responses. Dr. Skolnik also directs research concerning effective methods for HIV counseling and testing, linkage to care, and retention in care. Dr. Skolnik designs and directs clinical research protocols for HIV+ subjects including phase I, II, and III trials of antiretroviral drugs, immune-based therapies, adherence, and treatments for HIVassociated lipodystrophy.Toll-Like Receptor (TLR)-mediated innate immune responses, modeling of cytokine and chemokine networks, and the interactions of microRNAs with the innate immune system in the lungs of patients who are HIV-positive.

Selected Publications:

Peer Reviewed Publications

Clinical implications of elevated HIV-1 viral load results obtained from samples stored frozen in vacutainer plasma preparation tubes. Cloherty, Gavin; Swanson, Priscilla; Lucic, Danijela; Dieckhaus, Kevin; Anthony, Paul; Cataline, Philip; Herman, Christine; Hackett, John; Skolnik, Paul R; Chirch, Lisa. (2014). Journal of virological methods, (204), 91-2.

A low-effort, clinic-wide intervention improves attendance for HIV primary care. Gardner, Lytt I; Marks, Gary; Craw, Jason A; Wilson, Tracey E; Drainoni, Mari-Lynn; Moore, Richard D; Mugavero, Michael J; Rodriguez, Allan E; Bradley-Springer, Lucy A; Holman, Susan; Keruly, Jeanne C; Sullivan, Meg; Skolnik, Paul R; Malitz, Faye; Metsch, Lisa R; Raper, James L; Giordano, Thomas P; Drainoni, Mari-Lynn; Ferreira, Cintia; Koppelman, Lisa; Lewis, Roosevelt; McDoom, Maya; Naisteter, Michal; Osella, Karina; Ruiz, Glory; Sullivan, Meg; Gibbs-Cohen, Sophia; Desrivieres, Elana; Frederick, Mayange; Gravesande, Kevin; Holman, Susan; Johnson, Harry; Taylor, Tonya; Wilson, Tracey; Cheever, Laura; Malitz, Faye; Mills, Robert; Craw, Jason; Gardner, Lytt; Girde, Sonali; Marks, Gary; Batey, Scott; Gaskin, Stephanie; Mugavero, Michael; Murphree, Jill; Raper, Jim; Saag, Michael; Thogaripally, Suneetha; Willig, James; Zinski, Anne; Arya, Monisha; Bartholomew, David; Biggs, Tawanna; Budhwani, Hina; Davila, Jessica; Giordano, Thomas P; Miertschin, Nancy; Payne, Shapelle; Slaughter, William; Jenckes, Mollie; Keruly, Jeanne; McCray, Angie; McGann, Mary; Moore, Richard; Otterbein, Melissa; Zhou, Liming; Garzon, Carolyn; Jean-Simon, Jesline; Mercogliano, Kathy; Metsch, Lisa; Rodriguez, Allan; Saint-Jean, Gilbert; Shika, Marvin; Bradley-Springer, Lucy; Corwin, Marla. (2012). Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 8, (55), 1124-34.

Incidence and predictors of acute kidney injury in an urban cohort of subjects with HIV and hepatitis C virus coinfection. Garg, Shikha; Hoenig, Melanie; Edwards, Erika M; Bliss, Caleb; Heeren, Timothy; Tumilty, Sheila; Walley, Alexander Y; Koziel, Margaret J; Skolnik, Paul R; Horsburgh, C Robert; Cotton, Deborah. (2011). AIDS patient care and STDs, 3, (25), 135-41.

Randomized controlled trial of a personalized cellular phone reminder system to enhance adherence to antiretroviral therapy. Hardy, Helene; Kumar, Vikram; Doros, Gheorghe; Farmer, Eric; Drainoni, Mari-Lynn; Rybin, Denis; Myung, Dan; Jackson, Jonathan; Backman, Elke; Stanic, Anela; Skolnik, Paul R. (2011). AIDS patient care and STDs, 3, (25), 153-61.

Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. Wilkin, Timothy J; Su, Zhaohui; Krambrink, Amy; Long, Jianmin; Greaves, Wayne; Gross, Robert; Hughes, Michael D; Flexner, Charles; Skolnik, Paul R; Coakley, Eoin; Godfrey, Catherine; Hirsch, Martin; Kuritzkes, Daniel R; Gulick, Roy M. (2010). Journal of acquired immune deficiency syndromes (1999), 5, (54), 470-6.