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Ernesto Canalis, M.D.

Professor of Orthopaedic Surgery and Medicine, UConn Health
Director of Center for Skeletal Research, UConn Health
UConn Musculoskeletal Institute Biography


Overview:

Dr. Canalis is a professor of medicine and orthopaedics in the UConn Musculoskeletal Institute at UConn Health. He is an internationally renowned expert in bone metabolism. Dr. Canalis’ clinical interests include osteoporosis and metabolic bone disorders. He sees patients at the Center for Osteoporosis in the UConn Musculoskeletal Institute.



Specialties:
  • Osteoporosis
Office Locations:

Center for Osteoporosis
UConn Musculoskeletal Institute
UConn Health
263 Farmington Avenue
Farmington, CT 06030
860-679-2160

Board Certifications:
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
Education and Training:

TrainingInstitutionMajor/Specialty
Medical SchoolUniversidad Peruana Cayetano HerediaMedicine
InternshipUConn School of MedicineInternal Medicine
ResidencyHenry Ford HospitalInternal Medicine
ResidencyUConn School of MedicineInternal Medicine
FellowshipTufts-New England Medical CenterEndocrinology

Honors and Awards:
Name of Award/HonorAwarding Organization
Lawrence G. Raisz Award for Outstanding Achievements in Preclinical Translational ResearchAmerican Society for Bone and Mineral Research
Distinguished Physician Award, Medical StaffSaint Francis Hospital and Medical Center
Louis V. Avioli Founders Award for Fundamental Contributions to Bone and Mineral Basic ResearchAmerican Society for Bone and Mineral Research
Marshall Urist Award for Excellence in Tissue Regeneration ResearchOrthopaedic Research Society
Gerald D. Aurbach Award for Outstanding Research in EndocrinologyEndocrine Society
MERIT AwardNational Institute of Arthritis and Musculoskeletal and Skin Diseases
Ann Doner Vaughan Kappa Delta Award for Excellence in Orthopaedic ResearchAmerican Academy of Orthopaedic Surgeons
Hospital Affiliation:
  • John Dempsey Hospital
Research Interests:

The Canalis laboratory is known for the discovery of skeletal growth factors and has pursued important investigations on the role of growth factors and their antagonists in skeletal function.  Dr. Canalis’ group has made seminal contributions to our understanding of the mechanisms of glucocorticoid action in bone in an effort to explain the pathogenesis of glucocorticoid induced osteoporosis and correct the disease.  The laboratory’s recent work has centered on factors determining osteoblast cell fate and function.  These investigations include studies on the role of Notch signaling and Nuclear factor of activated T cells (NFAT) in osteoblastic cell differentiation.  Cellular and genetically engineered mouse models are used for the research conducted by the group.  The laboratory is particularly interested in translational research and has created genetically engineered mouse models of Hajdu Cheney Syndrome, a devastating disease characterized by bone loss and fractures.  The studies have allowed the team to determine mechanisms of the bone loss and are exploring ways to prevent the skeletal disease.The laboratory has been funded continuously by the National Institutes of Health (NIH) since the 1980’s, and in 1990 received a MERIT Award from the National Institute of Musculoskeletal and Skin Disorders (NIAMS).  Currently, the laboratory is funded by NIAMS, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Research on Women’s Health.



Languages Other than English:
  • Italian
  • Spanish
Selected Publications:

Peer Reviewed Publications

Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations. Canalis, Ernesto; Zanotti, Stefano. (2016). Current osteoporosis reports,

Effects of sex and notch signaling on the osteocyte cell pool. Canalis, Ernesto; Schilling, Lauren; Zanotti, Stefano. (2016). Journal of cellular physiology,

NOTCH SIGNALING AND THE SKELETON. Zanotti, Stefano; Canalis, Ernesto. (2016). Endocrine reviews, er20161002.

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis and Bone Resorption. Canalis, Ernesto; Schilling, Lauren; Yee, Siu-Pok; Lee, Sun-Kyeong; Zanotti, Stefano. (2015). The Journal of Biological Chemistry,

CANONICAL NOTCH ACTIVATION IN OSTEOCYTES CAUSES OSTEOPETROSIS. Canalis, Ernesto; Bridgewater, David; Schilling, Lauren; Zanotti, Stefano. (2015). American journal of physiology. Endocrinology and metabolism, ajpendo.00395.2015.

The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele. Zanotti, Stefano; Canalis, Ernesto. (2015). Journal of cellular biochemistry,

Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. DeMambro, Victoria E; Le, Phuong T; Guntur, Anyonya R; Maridas, David E; Canalis, Ernesto; Nagano, Kenichi; Baron, Roland; Clemmons, David R; Rosen, Clifford J. (2015). Endocrinology, 11, (156), 4129-40.

Management of endocrine disease: Secondary osteoporosis: pathophysiology and management. Mirza, Faryal; Canalis, Ernesto. (2015). European journal of endocrinology / European Federation of Endocrine Societies, 3, (173), R131-51.

Activation of Nfatc2 in osteoblasts causes osteopenia. Zanotti, Stefano; Canalis, Ernesto. (2015). Journal of cellular physiology, 7, (230), 1689-95.

Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice. Choudhary, Shilpa; Canalis, Ernesto; Estus, Thomas; Adams, Douglas; Pilbeam, Carol. (2015). PloS one, 3, (10), e0120164.

Hajdu-Cheney syndrome: a review. Canalis, Ernesto; Zanotti, Stefano. (2014). Orphanet journal of rare diseases, 1, (9), 200.

Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Canalis, Ernesto; Zanotti, Stefano; Smerdel-Ramoya, Anna. (2014). Bone, (64), 273-80.

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. Zanotti, Stefano; Canalis, Ernesto. (2014). Bone, (62), 22-8.

Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. He, Qing; Yang, Xuehui; Gong, Yan; Kovalenko, Dmitry; Canalis, Ernesto; Rosen, Clifford J; Friesel, Robert E. (2014). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 5, (29), 1217-31.

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor. Yang, Jibing; Velikoff, Miranda; Canalis, Ernesto; Horowitz, Jeffrey C; Kim, Kevin K. (2014). American journal of physiology. Lung cellular and molecular physiology, 8, (306), L786-96.

Nemo-like kinase regulates postnatal skeletal homeostasis. Canalis, Ernesto; Kranz, Lauren; Zanotti, Stefano. (2014). Journal of cellular physiology, 11, (229), 1736-43.

Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells. Zanotti, Stefano; Kalajzic, Ivo; Aguila, Hector Leonardo; Canalis, Ernesto. (2014). PloS one, 1, (9), e86757.

Osteoblast lineage-specific effects of notch activation in the skeleton. Canalis, Ernesto; Parker, Kristen; Feng, Jian Q; Zanotti, Stefano. (2013). Endocrinology, 2, (154), 623-34.

Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. Zanotti, Stefano; Smerdel-Ramoya, Anna; Canalis, Ernesto. (2013). The Journal of biological chemistry, 1, (288), 624-32.

Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Canalis, Ernesto; Brunet, Lisa J; Parker, Kristen; Zanotti, Stefano. (2012). Endocrinology, 4, (153), 1616-26.

Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. Zanotti, Stefano; Smerdel-Ramoya, Anna; Canalis, Ernesto. (2011). The Journal of biological chemistry, 6, (286), 4576-88.

HES1 (hairy and enhancer of split 1) is a determinant of bone mass. Zanotti, Stefano; Smerdel-Ramoya, Anna; Canalis, Ernesto. (2011). The Journal of biological chemistry, 4, (286), 2648-57.

BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. Beamer, Wesley G; Shultz, Kathryn L; Coombs, Harold F; DeMambro, Victoria E; Reinholdt, Laura G; Ackert-Bicknell, Cheryl L; Canalis, Ernesto; Rosen, Clifford J; Donahue, Leah Rae. (2011). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1, (26), 88-99.

Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation. Yang, Maobin; Trettel, Lorin B; Adams, Douglas J; Harrison, John R; Canalis, Ernesto; Kream, Barbara E. (2010). Bone, 3, (47), 573-82.

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Canalis, Ernesto; Zanotti, Stefano; Beamer, Wesley G; Economides, Aris N; Smerdel-Ramoya, Anna. (2010). Endocrinology, 8, (151), 3490-501.

Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage. Smerdel-Ramoya, Anna; Zanotti, Stefano; Canalis, Ernesto. (2010). Journal of cellular biochemistry, 2, (110), 477-83.

Update in new anabolic therapies for osteoporosis. Canalis, Ernesto. (2010). The Journal of clinical endocrinology and metabolism, 4, (95), 1496-504.

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. DeMambro, Victoria E; Kawai, Masanobu; Clemens, Thomas L; Fulzele, Keertik; Maynard, Jane A; Marín de Evsikova, Caralina; Johnson, Kenneth R; Canalis, Ernesto; Beamer, Wesley G; Rosen, Clifford J; Donahue, Leah Rae. (2010). The Journal of endocrinology, 3, (204), 241-53.

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Canalis, Ernesto; Smerdel-Ramoya, Anna; Durant, Deena; Economides, Aris N; Beamer, Wesley G; Zanotti, Stefano. (2010). Endocrinology, 1, (151), 221-33.

Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. Yakar, Shoshana; Canalis, Ernesto; Sun, Hui; Mejia, Wilson; Kawashima, Yuki; Nasser, Philip; Courtland, Hayden-William; Williams, Valerie; Bouxsein, Mary; Rosen, Clifford; Jepsen, Karl J. (2009). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8, (24), 1481-92.

Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. Zanotti, Stefano; Stadmeyer, Lisa; Smerdel-Ramoya, Anna; Durant, Deena; Canalis, Ernesto. (2009). The Journal of endocrinology, 2, (201), 263-74.

PPARG by dietary fat interaction influences bone mass in mice and humans. Ackert-Bicknell, Cheryl L; Demissie, Serkalem; Marín de Evsikova, Caralina; Hsu, Yi-Hsiang; DeMambro, Victoria E; Karasik, David; Cupples, L Adrienne; Ordovas, Jose M; Tucker, Katherine L; Cho, Kelly; Canalis, Ernesto; Paigen, Beverly; Churchill, Gary A; Forejt, Jiri; Beamer, Wesley G; Ferrari, Serge; Bouxsein, Mary L; Kiel, Douglas P; Rosen, Clifford J. (2008). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9, (23), 1398-408.

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Smerdel-Ramoya, Anna; Zanotti, Stefano; Stadmeyer, Lisa; Durant, Deena; Canalis, Ernesto. (2008). Endocrinology, 9, (149), 4374-81.

Connective tissue growth factor enhances osteoblastogenesis in vitro. Smerdel-Ramoya, Anna; Zanotti, Stefano; Deregowski, Valerie; Canalis, Ernesto. (2008). The Journal of biological chemistry, 33, (283), 22690-9.

Growth hormone, insulin-like growth factors, and the skeleton. Giustina, Andrea; Mazziotti, Gherardo; Canalis, Ernesto. (2008). Endocrine reviews, 5, (29), 535-59.

Notch inhibits osteoblast differentiation and causes osteopenia. Zanotti, Stefano; Smerdel-Ramoya, Anna; Stadmeyer, Lisa; Durant, Deena; Radtke, Freddy; Canalis, Ernesto. (2008). Endocrinology, 8, (149), 3890-9.

Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2. Zanotti, Stefano; Smerdel-Ramoya, Anna; Stadmeyer, Lisa; Canalis, Ernesto. (2008). Journal of cellular biochemistry, 4, (104), 1421-6.

A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Pearsall, R Scott; Canalis, Ernesto; Cornwall-Brady, Milton; Underwood, Kathryn W; Haigis, Brendan; Ucran, Jeffrey; Kumar, Ravindra; Pobre, Eileen; Grinberg, Asya; Werner, Eric D; Glatt, Vaida; Stadmeyer, Lisa; Smith, Deanna; Seehra, Jasbir; Bouxsein, Mary L. (2008). Proceedings of the National Academy of Sciences of the United States of America, 19, (105), 7082-7.

Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice. DeMambro, V E; Clemmons, D R; Horton, L G; Bouxsein, M L; Wood, T L; Beamer, W G; Canalis, E; Rosen, C J. (2008). Endocrinology, 5, (149), 2051-61.

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Raz, Regina; Stricker, Sigmar; Gazzerro, Elizabetta; Clor, Julie L; Witte, Florian; Nistala, Harakiran; Zabski, Stefanie; Pereira, Renata C; Stadmeyer, Lisa; Wang, Xiangmin; Gowen, Lori; Sleeman, Mark W; Yancopoulos, George D; Canalis, Ernesto; Mundlos, Stefan; Valenzuela, David M; Economides, Aris N. (2008). Development (Cambridge, England), 9, (135), 1713-23.

Transgenic overexpression of gremlin results in developmental defects in enamel and dentin in mice. Nagatomo, Kanako J; Tompkins, Kevin A; Fong, Hanson; Zhang, Hai; Foster, Brian L; Chu, Emily Y; Murakami, Ayu; Stadmeyer, Lisa; Canalis, Ernesto; Somerman, Martha J. (2008). Connective tissue research, 6, (49), 391-400.

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. Gazzerro, Elisabetta; Smerdel-Ramoya, Anna; Zanotti, Stefano; Stadmeyer, Lisa; Durant, Deena; Economides, Aris N; Canalis, Ernesto. (2007). The Journal of biological chemistry, 43, (282), 31549-57.

Mechanisms of anabolic therapies for osteoporosis. Canalis, Ernesto; Giustina, Andrea; Bilezikian, John P. (2007). The New England journal of medicine, 9, (357), 905-16.

Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes. Beamer, Wesley G; Shultz, Kathryn L; Ackert-Bicknell, Cheryl L; Horton, Lindsay G; Delahunty, Krista M; Coombs, Harold F; Donahue, Leah R; Canalis, Ernesto; Rosen, Clifford J. (2007). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8, (22), 1187-96.

Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. Glatt, Vaida; Canalis, Ernesto; Stadmeyer, Lisa; Bouxsein, Mary L. (2007). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8, (22), 1197-207.

Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. Rydziel, Sheila; Stadmeyer, Lisa; Zanotti, Stefano; Durant, Deena; Smerdel-Ramoya, Anna; Canalis, Ernesto. (2007). The Journal of biological chemistry, 27, (282), 19762-72.

CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Pereira, Renata C; Stadmeyer, Lisa E; Smith, Deanna L; Rydziel, Sheila; Canalis, Ernesto. (2007). Bone, 3, (40), 619-26.

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Gazzerro, Elisabetta; Deregowski, Valerie; Stadmeyer, Lisa; Gale, Nickolas W; Economides, Aris N; Canalis, Ernesto. (2006). Bone, 6, (39), 1252-60.

Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage. Deregowski, Valerie; Gazzerro, Elisabetta; Priest, Leah; Rydziel, Sheila; Canalis, Ernesto. (2006). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8, (21), 1317-26.

Expression and regulation of CCN genes in murine osteoblasts. Parisi, Muriel S; Gazzerro, Elizabetta; Rydziel, Sheila; Canalis, Ernesto. (2006). Bone, 5, (38), 671-7.

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. Yakar, Shoshana; Bouxsein, Mary L; Canalis, Ernesto; Sun, Hui; Glatt, Vaida; Gundberg, Caren; Cohen, Pinchas; Hwang, David; Boisclair, Yves; Leroith, Derek; Rosen, Clifford J. (2006). The Journal of endocrinology, 2, (189), 289-99.

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. Deregowski, Valerie; Gazzerro, Elisabetta; Priest, Leah; Rydziel, Sheila; Canalis, Ernesto. (2006). The Journal of biological chemistry, 10, (281), 6203-10.

C/EBP homologous protein is necessary for normal osteoblastic function. Pereira, Renata C; Stadmeyer, Lisa; Marciniak, Stefan J; Ron, David; Canalis, Ernesto. (2006). Journal of cellular biochemistry, 3, (97), 633-40.

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro. Gazzerro, Elisabetta; Deregowski, Valerie; Vaira, Sergio; Canalis, Ernesto. (2005). Endocrinology, 9, (146), 3875-82.

Overexpression of IGF-binding protein 5 alters mineral and matrix properties in mouse femora: an infrared imaging study. Atti, E; Boskey, A L; Canalis, E. (2005). Calcified tissue international, 3, (76), 187-93.

Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. Varghese, Samuel; Rydziel, Sheila; Canalis, Ernesto. (2005). Journal of cellular physiology, 2, (202), 391-9.

AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts. Rydziel, Sheila; Delany, Anne M; Canalis, Ernesto. (2004). The Journal of biological chemistry, 7, (279), 5397-404.

Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro. Durant, D; Pereira, R M R; Canalis, E. (2004). Bone, 6, (35), 1256-62.

Effects of activated T cells on osteoclastogenesis depend on how they are activated. Wyzga, Nancy; Varghese, Samuel; Wikel, Stephen; Canalis, Ernesto; Sylvester, Francisco A. (2004). Bone, 3, (35), 614-20.

Transgenic mice expressing selected insulin-like growth factor-binding protein-5 fragments do not exhibit enhanced bone formation. Durant, D; Pereira, R; Stadmeyer, L; Canalis, E. (2004). Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 4, (14), 319-27.

Perspectives on glucocorticoid-induced osteoporosis. Canalis, Ernesto; Bilezikian, John P; Angeli, Alberto; Giustina, Andrea. (2004). Bone, 4, (34), 593-8.

CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. Pereira, Renata C; Delany, Anne M; Canalis, Ernesto. (2004). Endocrinology, 4, (145), 1952-60.

Notch 1 impairs osteoblastic cell differentiation. Sciaudone, Maria; Gazzerro, Elisabetta; Priest, Leah; Delany, Anne M; Canalis, Ernesto. (2003). Endocrinology, 12, (144), 5631-9.

Transcriptional regulation of collagenase-3 by interleukin-1 alpha in osteoblasts. Varghese, Samuel; Canalis, Ernesto. (2003). Journal of cellular biochemistry, 5, (90), 1007-14.

Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. Boskey, Adele L; Moore, David J; Amling, Michael; Canalis, Ernesto; Delany, Anne M. (2003). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 6, (18), 1005-11.

Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Delany, Anne M; Kalajzic, Ivo; Bradshaw, Amy D; Sage, E Helene; Canalis, Ernesto. (2003). Endocrinology, 6, (144), 2588-96.

Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Devlin, R D; Du, Z; Pereira, R C; Kimble, R B; Economides, A N; Jorgetti, V; Canalis, E. (2003). Endocrinology, 5, (144), 1972-8.

Bone morphogenetic proteins, their antagonists, and the skeleton. Canalis, Ernesto; Economides, Aris N; Gazzerro, Elisabetta. (2003). Endocrine reviews, 2, (24), 218-35.

Noggin arrests stromal cell differentiation in vitro. Gazzerro, E; Du, Z; Devlin, R D; Rydziel, S; Priest, L; Economides, A N; Canalis, E. (2003). Bone, 2, (32), 111-9.

Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. Devlin, R D; Du, Z; Buccilli, V; Jorgetti, V; Canalis, E. (2002). Endocrinology, 10, (143), 3955-62.

Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Pereira, R C; Delany, A M; Canalis, Ernesto. (2002). Bone, 5, (30), 685-91.

Cortisol regulates the expression of Notch in osteoblasts. Pereira, Rosa M R; Delany, Anne M; Durant, Deena; Canalis, Ernesto. (2002). Journal of cellular biochemistry, 2, (85), 252-8.

Glucocorticoid suppression of IGF I transcription in osteoblasts. Delany, A M; Durant, D; Canalis, E. (2001). Molecular endocrinology (Baltimore, Md.), 10, (15), 1781-9.

Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Pereira, R M; Delany, A M; Canalis, E. (2001). Bone, 5, (28), 484-90.

The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts. Delany, A M; Canalis, E. (2001). Endocrinology, 4, (142), 1561-6.

Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Pereira, R C; Economides, A N; Canalis, E. (2000). Endocrinology, 12, (141), 4558-63.

Alendronate stimulates collagenase 3 expression in osteoblasts by posttranscriptional mechanisms. Varghese, S; Canalis, E. (2000). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12, (15), 2345-51.

Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. Pereira, R C; Durant, D; Canalis, E. (2000). American journal of physiology. Endocrinology and metabolism, 3, (279), E570-6.

Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex. Rydziel, S; Durant, D; Canalis, E. (2000). Journal of cellular physiology, 3, (184), 326-33.

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese, S; Rydziel, S; Canalis, E. (2000). Endocrinology, 6, (141), 2185-91.

Osteopenia and decreased bone formation in osteonectin-deficient mice. Delany, AM; Amling, M; Priemel, M; Howe, C; Baron, R; Canalis, E. (2000). The Journal of clinical investigation, 9, (105), 1325.

Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts. Blanquaert, F; Pereira, R C; Canalis, E. (2000). American journal of physiology. Endocrinology and metabolism, 3, (278), E509-15.

Transforming growth factor-beta increases interleukin-6 transcripts in osteoblasts. Franchimont, N; Rydziel, S; Canalis, E. (2000). Bone, 3, (26), 249-53.

Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts. Pereira, R C; Rydziel, S; Canalis, E. (2000). Journal of cellular physiology, 2, (182), 239-46.

Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts. Pereira, R C; Jorgetti, V; Canalis, E. (1999). The American journal of physiology, 3 Pt 1, (277), E496-504.

Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts. Pereira, R C; Canalis, E. (1999). Endocrinology, 5, (140), 1998-2003.

Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. Franchimont, N; Durant, D; Rydziel, S; Canalis, E. (1999). The Journal of biological chemistry, 10, (274), 6783-9.

Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts. Blanquaert, F; Delany, A M; Canalis, E. (1999). Endocrinology, 3, (140), 1069-74.

Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. Varghese, S; Yu, K; Canalis, E. (1999). The American journal of physiology, 3 Pt 1, (276), E465-71.

Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts. Gazzerro, E; Rydziel, S; Canalis, E. (1999). Endocrinology, 2, (140), 562-7.

Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts. Pereira, R C; Blanquaert, F; Canalis, E. (1999). Endocrinology, 1, (140), 228-32.

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. Gazzerro, E; Gangji, V; Canalis, E. (1998). The Journal of clinical investigation, 12, (102), 2106-14.

Regulation of insulin-like growth factors I and II and their binding proteins in human bone marrow stromal cells by dexamethasone. Cheng, S L; Zhang, S F; Mohan, S; Lecanda, F; Fausto, A; Hunt, A H; Canalis, E; Avioli, L V. (1998). Journal of cellular biochemistry, 3, (71), 449-58.

Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. Gabbitas, B; Canalis, E. (1998). The American journal of physiology, 2 Pt 1, (275), E222-8.

Dual regulation of stromelysin-3 by fibroblast growth factor-2 in murine osteoblasts. Delany, A M; Canalis, E. (1998). The Journal of biological chemistry, 26, (273), 16595-600.

Insulin-like growth factor II promoter expression in cultured rodent osteoblasts and adult rat bone. Gangji, V; Rydziel, S; Gabbitas, B; Canalis, E. (1998). Endocrinology, 5, (139), 2287-92.

Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. Delany, A M; Canalis, E. (1998). The American journal of physiology, 3 Pt 1, (274), C734-40.

Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. Franchimont, N; Gangji, V; Durant, D; Canalis, E. (1997). Endocrinology, 12, (138), 5248-55.

Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures. Rydziel, S; Delany, A M; Canalis, E. (1997). Journal of cellular biochemistry, 2, (67), 176-83.

Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells. Franchimont, N; Rydziel, S; Canalis, E. (1997). The Journal of clinical investigation, 7, (100), 1797-803.

Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Franchimont, N; Durant, D; Canalis, E. (1997). Endocrinology, 8, (138), 3380-6.

Retinoic acid regulates the expression of insulin-like growth factors I and II in osteoblasts. Gabbitas, B; Canalis, E. (1997). Journal of cellular physiology, 2, (172), 253-64.

Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts. Gabbitas, B; Canalis, E. (1997). Journal of cellular biochemistry, 1, (66), 77-86.

Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures. Franchimont, N; Rydziel, S; Delany, A M; Canalis, E. (1997). The Journal of biological chemistry, 18, (272), 12144-50.

Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. Varghese, S; Canalis, E. (1997). Endocrinology, 3, (138), 1035-40.

Transforming growth factor beta1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures. Rydziel, S; Varghese, S; Canalis, E. (1997). Journal of cellular physiology, 2, (170), 145-52.

Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. Delany, A M; Rydziel, S; Canalis, E. (1996). Endocrinology, 11, (137), 4665-70.

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. Canalis, E. (1996). The Journal of clinical endocrinology and metabolism, 10, (81), 3441-7.

Retinoic acid stimulates the transcription of insulin-like growth factor binding protein-6 in skeletal cells. Gabbitas, B; Canalis, E. (1996). Journal of cellular physiology, 1, (169), 15-22.

Expression and growth factor regulation of platelet-derived growth factor B transcripts in primary osteoblast cell cultures. Rydziel, S; Canalis, E. (1996). Endocrinology, 10, (137), 4115-9.

The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Canalis, E; Hott, M; Deloffre, P; Tsouderos, Y; Marie, P J. (1996). Bone, 6, (18), 517-23.

Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells. Pash, J M; Canalis, E. (1996). Endocrinology, 6, (137), 2375-82.

Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts. Gabbitas, B; Canalis, E. (1996). Endocrinology, 5, (137), 1687-92.

Cortisol inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures by transcriptional mechanisms. Gabbitas, B; Pash, J M; Delany, A M; Canalis, E. (1996). The Journal of biological chemistry, 15, (271), 9033-8.

Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures. Varghese, S; Delany, A M; Liang, L; Gabbitas, B; Jeffrey, J J; Canalis, E. (1996). Endocrinology, 2, (137), 431-7.

Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. Franchimont, N; Canalis, E. (1995). Endocrinology, 12, (136), 5469-75.

Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms. Delany, A M; Jeffrey, J J; Rydziel, S; Canalis, E. (1995). The Journal of biological chemistry, 44, (270), 26607-12.

Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. Delany, A M; Canalis, E. (1995). Endocrinology, 11, (136), 4776-81.

Cortisol represses insulin-like growth factor II receptor transcription in skeletal cell cultures. Rydziel, S; Canalis, E. (1995). Endocrinology, 10, (136), 4254-60.

Bone morphogenetic protein-2 inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures. Gabbitas, B; Canalis, E. (1995). Endocrinology, 6, (136), 2397-403.

Skeletal growth factors regulate the synthesis of insulin-like growth factor binding protein-5 in bone cell cultures. Canalis, E; Gabbitas, B. (1995). The Journal of biological chemistry, 18, (270), 10771-6.

Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells. Dong, Y; Canalis, E. (1995). Endocrinology, 5, (136), 2000-6.

Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells. Varghese, S; Ramsby, M L; Jeffrey, J J; Canalis, E. (1995). Endocrinology, 5, (136), 2156-62.

Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures. Canalis, E; Rydziel, S; Delany, A M; Varghese, S; Jeffrey, J J. (1995). Endocrinology, 4, (136), 1348-54.

Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms. Delany, A M; Gabbitas, B Y; Canalis, E. (1995). Journal of cellular biochemistry, 3, (57), 488-94.

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells. Pash, J M; Delany, A M; Adamo, M L; Roberts, C T; LeRoith, D; Canalis, E. (1995). Endocrinology, 1, (136), 33-8.

Bone morphogenetic protein 2 increases insulin-like growth factor I and II transcripts and polypeptide levels in bone cell cultures. Canalis, E; Gabbitas, B. (1994). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12, (9), 1999-2005.

Mechanisms of glucocorticoid action in bone cells. Delany, A M; Dong, Y; Canalis, E. (1994). Journal of cellular biochemistry, 3, (56), 295-302.

Differential effects of warfarin on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix GLA protein in vitro. Barone, L M; Aronow, M A; Tassinari, M S; Conlon, D; Canalis, E; Stein, G S; Lian, J B. (1994). Journal of cellular physiology, 2, (160), 255-64.

Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors. Gabbitas, B; Pash, J; Canalis, E. (1994). Endocrinology, 1, (135), 284-9.

Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. McCarthy, T L; Casinghino, S; Centrella, M; Canalis, E. (1994). Journal of cellular physiology, 1, (160), 163-75.

Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures. Rydziel, S; Shaikh, S; Canalis, E. (1994). Endocrinology, 6, (134), 2541-6.

Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells. Varghese, S; Rydziel, S; Jeffrey, J J; Canalis, E. (1994). Endocrinology, 6, (134), 2438-44.

Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. Hock, J M; Canalis, E. (1994). Endocrinology, 3, (134), 1423-8.

Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I. Raisz, L G; Fall, P M; Gabbitas, B Y; McCarthy, T L; Kream, B E; Canalis, E. (1993). Endocrinology, 4, (133), 1504-10.

Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Canalis, E; Pash, J; Gabbitas, B; Rydziel, S; Varghese, S. (1993). Endocrinology, 1, (133), 33-8.

Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells. Canalis, E; Avioli, L. (1992). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9, (7), 1085-92.

Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone. Centrella, M; McCarthy, T L; Kusmik, W F; Canalis, E. (1992). The Journal of clinical investigation, 4, (89), 1076-84.

Determination and expression of platelet-derived growth factor-AA in bone cell cultures. Rydziel, S; Ladd, C; McCarthy, T L; Centrella, M; Canalis, E. (1992). Endocrinology, 4, (130), 1916-22.

Constitutive synthesis of insulin-like growth factor-II by primary osteoblast-enriched cultures from fetal rat calvariae. McCarthy, T L; Centrella, M; Canalis, E. (1992). Endocrinology, 3, (130), 1303-8.

Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone. Centrella, M; McCarthy, T L; Canalis, E. (1991). Molecular and cellular biology, 9, (11), 4490-6.

Effects of desamino-(1-3)-insulin-like growth factor I on bone cell function in rat calvarial cultures. Canalis, E; McCarthy, T L; Centrella, M. (1991). Endocrinology, 1, (129), 534-41.

Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet-derived growth factor in osteoblast-enriched cultures from fetal rat bone. Centrella, M; McCarthy, T L; Kusmik, W F; Canalis, E. (1991). Journal of cellular physiology, 3, (147), 420-6.

Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. McCarthy, T L; Centrella, M; Raisz, L G; Canalis, E. (1991). Endocrinology, 6, (128), 2895-900.

Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone. Centrella, M; McCarthy, T L; Canalis, E. (1991). Molecular and cellular biology, 1, (11), 250-8.

Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures. McCarthy, T L; Centrella, M; Canalis, E. (1990). The Journal of biological chemistry, 26, (265), 15353-6.

Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells. ten Dijke, P; Iwata, K K; Goddard, C; Pieler, C; Canalis, E; McCarthy, T L; Centrella, M. (1990). Molecular and cellular biology, 9, (10), 4473-9.

Differential effects of continuous and transient treatment with parathyroid hormone related peptide (PTHrp) on bone collagen synthesis. Canalis, E; McCarthy, T L; Centrella, M. (1990). Endocrinology, 4, (126), 1806-12.

Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells. McCarthy, T L; Centrella, M; Canalis, E. (1990). Endocrinology, 3, (126), 1569-75.

Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone. Centrella, M; McCarthy, T L; Canalis, E. (1990). Endocrinology, 1, (126), 39-44.

Transforming growth factor-beta stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae. Hock, J M; Canalis, E; Centrella, M. (1990). Endocrinology, 1, (126), 421-6.

Beta 2-microglobulin enhances insulin-like growth factor I receptor levels and synthesis in bone cell cultures. Centrella, M; McCarthy, T L; Canalis, E. (1989). The Journal of biological chemistry, 31, (264), 18268-71.

Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. McCarthy, T L; Centrella, M; Canalis, E. (1989). Endocrinology, 4, (125), 2118-26.

Effects of platelet-derived growth factor on bone formation in vitro. Canalis, E; McCarthy, T L; Centrella, M. (1989). Journal of cellular physiology, 3, (140), 530-7.

Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells. Centrella, M; Canalis, E; McCarthy, T L; Stewart, A F; Orloff, J J; Insogna, K L. (1989). Endocrinology, 1, (125), 199-208.

Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone. Centrella, M; McCarthy, T L; Canalis, E. (1989). Endocrinology, 1, (125), 13-9.

Analysis of hydroxyproline by high performance liquid chromatography and its application to collagen turnover studies in bone cultures. Rydziel, S; Canalis, E. (1989). Calcified tissue international, 6, (44), 421-4.

Scanning electron microscopy and gel electrophoresis of vascularized periosteal autografts. Burstein, F D; Canalis, R F; Canalis, E M; Ariyan, S. (1989). Plastic and reconstructive surgery, 3, (83), 500-10.

Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. McCarthy, T L; Centrella, M; Canalis, E. (1989). Endocrinology, 3, (124), 1247-53.

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. Canalis, E; Centrella, M; Burch, W; McCarthy, T L. (1989). The Journal of clinical investigation, 1, (83), 60-5.

Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. McCarthy, T L; Centrella, M; Canalis, E. (1989). Endocrinology, 1, (124), 301-9.

Isolation of growth factors from adult bovine bone. Canalis, E; McCarthy, T; Centrella, M. (1988). Calcified tissue international, 6, (43), 346-51.

Skeletal tissue and transforming growth factor beta. Centrella, M; McCarthy, T L; Canalis, E. (1988). FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15, (2), 3066-73.

Tumor necrosis factor-alpha inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxyribonucleic acid synthesis in osteoblast-enriched bone cell cultures. Centrella, M; McCarthy, T L; Canalis, E. (1988). Endocrinology, 3, (123), 1442-8.

Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone. Centrella, M; McCarthy, T L; Canalis, E. (1988). Proceedings of the National Academy of Sciences of the United States of America, 16, (85), 5889-93.

Further biochemical and molecular characterization of primary rat parietal bone cell cultures. McCarthy, T L; Centrella, M; Canalis, E. (1988). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 4, (3), 401-8.

Effects of basic fibroblast growth factor on bone formation in vitro. Canalis, E; Centrella, M; McCarthy, T. (1988). The Journal of clinical investigation, 5, (81), 1572-7.

Growth factors and the regulation of bone remodeling. Canalis, E; McCarthy, T; Centrella, M. (1988). The Journal of clinical investigation, 2, (81), 277-81.

Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae. Canalis, E; Lian, J B. (1988). Bone, 4, (9), 243-6.

Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae. Canalis, E; McCarthy, T; Centrella, M. (1988). Endocrinology, 1, (122), 22-7.

Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Hock, J M; Centrella, M; Canalis, E. (1988). Endocrinology, 1, (122), 254-60.

Effects of tumor necrosis factor on bone formation in vitro. Canalis, E. (1987). Endocrinology, 5, (121), 1596-604.

Mitogenesis in fetal rat bone cells simultaneously exposed to type beta transforming growth factor and other growth regulators. Centrella, M; McCarthy, T L; Canalis, E. (1987). FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 4, (1), 312-7.

A bone-derived growth factor isolated from rat calvariae is beta 2 microglobulin. Canalis, E; McCarthy, T; Centrella, M. (1987). Endocrinology, 3, (121), 1198-200.

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. Centrella, M; McCarthy, T L; Canalis, E. (1987). The Journal of biological chemistry, 6, (262), 2869-74.

Isolation of EGF-dependent transforming growth factor (TGF beta-like) activity from culture medium conditioned by fetal rat calvariae. Centrella, M; Canalis, E. (1987). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1, (2), 29-36.

Effects of endothelial cell growth factor on bone remodelling in vitro. Canalis, E; Lorenzo, J; Burgess, W H; Maciag, T. (1987). The Journal of clinical investigation, 1, (79), 52-8.

Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae. Centrella, M; Massagué, J; Canalis, E. (1986). Endocrinology, 5, (119), 2306-12.

Isolation of a nontransforming bone-derived growth factor from medium conditioned by fetal rat calvariae. Canalis, E; Centrella, M. (1986). Endocrinology, 5, (118), 2002-8.

Interleukin-1 has independent effects on deoxyribonucleic acid and collagen synthesis in cultures of rat calvariae. Canalis, E. (1986). Endocrinology, 1, (118), 74-81.

Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae. Centrella, M; Canalis, E. (1985). Proceedings of the National Academy of Sciences of the United States of America, 21, (82), 7335-9.

Effect of partially purified bone morphogenetic protein on DNA synthesis and cell replication in calvarial and fibroblast cultures. Canalis, E; Centrella, M; Urist, M R. (1985). Clinical orthopaedics and related research, 198, 289-96.

Studies of hormonal regulation of osteocalcin synthesis in cultured fetal rat calvariae. Lian, J B; Coutts, M; Canalis, E. (1985). The Journal of biological chemistry, 15, (260), 8706-10.

Effect of sodium vanadate on deoxyribonucleic acid and protein syntheses in cultured rat calvariae. Canalis, E. (1985). Endocrinology, 3, (116), 855-62.

1,25-Dihydroxyvitamin D3 effects on collagen and DNA synthesis in periosteum and periosteum-free calvaria. Canalis, E; Lian, J B. (1985). Bone, 6, (6), 457-60.

Local regulators of skeletal growth: a perspective. Centrella, M; Canalis, E. (1985). Endocrine reviews, 4, (6), 544-51.

Characterization of the effect of insulin on collagen synthesis in fetal rat bone. Kream, B E; Smith, M D; Canalis, E; Raisz, L G. (1985). Endocrinology, 1, (116), 296-302.

Effect of cortisol on periosteal and nonperiosteal collagen and DNA synthesis in cultured rat calvariae. Canalis, E. (1984). Calcified tissue international, 2, (36), 158-66.

Effect of cartilage-derived factor on DNA and protein synthesis in cultured rat calvariae. Canalis, E; Kato, Y; Hiraki, Y; Suzuki, F. (1984). Calcified tissue international, 1, (36), 102-7.

Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae. Canalis, E. (1983). Endocrinology, 3, (112), 931-9.

Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae. Canalis, E. (1983). Metabolism: clinical and experimental, 1, (32), 14-20.

A more specific, liquid-chromatographic method for free cortisol in urine. Canalis, E; Reardon, G E; Caldarella, A M. (1982). Clinical chemistry, 12, (28), 2418-20.

Effect of bone-derived growth factor on DNA, RNA, and proteoglycan synthesis in cultures of rabbit costal chondrocytes. Kato, Y; Watanabe, R; Nomura, Y; Tsuji, M; Suzuki, F; Raisz, L G; Canalis, E. (1982). Metabolism: clinical and experimental, 8, (31), 812-5.

Selective stimulation of sulfated glycosaminoglycan synthesis by multiplication-stimulating activity, cartilage-derived factor and bone-derived growth factor. Comparison of their actions on cultured chondrocytes with those of fibroblast growth factor and Rhodamine fibrosarcoma-derived growth factor. Kato, Y; Watanabe, R; Hiraki, Y; Suzuki, F; Canalis, E; Raisz, L G; Nishikawa, K; Adachi, K. (1982). Biochimica et biophysica acta, 2, (716), 232-9.

Analysis for cortisol in serum by liquid chromatography. Caldarella, A M; Reardon, G E; Canalis, E. (1982). Clinical chemistry, 3, (28), 538-43.

Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. Canalis, E. (1981). Metabolism: clinical and experimental, 10, (30), 970-5.

Determination of serum 17 alpha-hydroxyprogesterone by liquid chromatography. Canalis, E; Caldarella, A M; Reardon, G E. (1981). Clinical chemistry, 7, (27), 1241-3.

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria. Canalis, E; Peck, W A; Raisz, L G. (1980). Science (New York, N.Y.), 4473, (210), 1021-3.

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria. Canalis, E. (1980). The Journal of clinical investigation, 4, (66), 709-19.

The generation of sulfation factor activity by proteolytic modification of growth hormone. Maciag, T; Forand, R; Ilsley, S; Cerundolo, J; Greenlee, R; Kelley, P R; Canalis, E. (1980). The Journal of biological chemistry, 13, (255), 6064-70.

Direct stimulation of bone resorption by epidermal growth factor. Raisz, L G; Simmons, H A; Sandberg, A L; Canalis, E. (1980). Endocrinology, 1, (107), 270-3.

Hyperparathyroidism in the elderly. Mannix, H; Pyrtek, L J; Crombie, H D; Canalis, E. (1980). American journal of surgery, 4, (139), 581-5.

Effect of fibroblast growth factor on cultured fetal rat calvaria. Canalis, E; Raisz, L G. (1980). Metabolism: clinical and experimental, 2, (29), 108-14.

Serum cortisol and 11 deoxycortisol by liquid chromatography: clinical studies and comparison with radioimmunoassay. Canalis, E; Caldarella, A M; Reardon, G E. (1979). Clinical chemistry, 10, (25), 1700-3.

Effect of epidermal growth factor on bone formation in vitro. Canalis, E; Raisz, L G. (1979). Endocrinology, 4, (104), 862-9.

Effects of glucocorticoids on fetal rat bone collagen synthesis in vitro. Dietrich, J W; Canalis, E M; Maina, D M; Raisz, L G. (1979). Endocrinology, 3, (104), 715-21.

Determination of serum cortisol and 11-deoxycortisol by liquid chromatography. Reardon, G E; Caldarella, A M; Canalis, E. (1979). Clinical chemistry, 1, (25), 122-6.

Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming. Seyler, L E; Canalis, E; Spare, S; Reichlin, S. (1978). The Journal of clinical endocrinology and metabolism, 1, (47), 176-83.

Effect of sex steroids on bone collagen synthesis in vitro. Canalis, E; Raisz, L G. (1978). Calcified tissue research, 2, (25), 105-10.

Hormonal control of bone collagen synthesis in vitro: inhibitory effect of 1-hydroxylated vitamin D metabolites. Raisz, L G; Maina, D M; Gworek, S C; Dietrich, J W; Canalis, E M. (1978). Endocrinology, 3, (102), 731-5.

Effect of somatomedin and growth hormone on bone collagen synthesis in vitro. Canalis, E M; Hintz, R L; Dietrich, J W; Maina, D M; Raisz, L G. (1977). Metabolism: clinical and experimental, 10, (26), 1079-87.

Hormonal control of bone collagen synthesis in vitro. Effects of insulin and glucagon. Canalis, E M; Dietrich, J W; Maina, D M; Raisz, L G. (1977). Endocrinology, 3, (100), 668-74.

Direct stimulation of bone resorption by thyroid hormones. Mundy, G R; Shapiro, J L; Bandelin, J G; Canalis, E M; Raisz, L G. (1976). The Journal of clinical investigation, 3, (58), 529-34.

Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin. Dietrich, J W; Canalis, E M; Maina, D M; Raisz, L G. (1976). Endocrinology, 4, (98), 943-9.

Factors influencing bone formation in organ culture. Raisz, L G; Dietrich, J W; Canalis, E M. (1976). Israel journal of medical sciences, 2, (12), 108-14.